A person who once saw himself in the lap of nature, today, his relationship with nature has turned into domination. Therefore, due to the deep gap between man and nature, the presence of nature or its strengthening in the city is considered one of the essential factors in today’s urban design. There should be a favorable relationship between the city as a part and nature as a whole. Established The premise of biophilia is that we, as a species, have an innate connection to nature. When nature is around us, where we live and work, we are happier, healthier, and able to live more meaningful lives. Biophilic designers and planners argue that integrating nature into urban design and planning is an essential step towards It is towards the cities of the future that are uplifting, restorative, beautiful, and designed around a sense of connection with the natural world and the wonder about it. The purpose of this article is to determine the mission of the relationship between the city and nature over time and to answer the question of how the relationship between the city and nature has been from the past (prehistory) to now. This research has been carried out in a descriptive-analytical way and tries to understand the evolution of the relationship between cities and nature over time with a structural view. The documentary method has been used to collect information. The research results have shown that according to prehistoric urban planning, the city was built by the surrounding natural environment, and there were gardens and agricultural lands around the cities. According to the urban planning of the historical period after Islam, the physical structure of some cities has been mixed with natural elements and unique green spaces, so nature has brought other dimensions of identity under its radius. However, in the last century, with the change of perspective in thought and with a physical view of the landscape, nature has become a capital for exploitation. In this way, in a process contrary to the past, man gets closer to nature, expands his living space towards it, and, in this direction, flattens the earth and clears the forest. Therefore, nature is no longer an identifiable and valuable element in the mind of its audience.